S2673
RTT - Patient experience and quality of life
ESTRO 2026
were identified by comparing planned and actual treatment durations, and all identified events were verified and classified through individual case review. Only interruptions due to medical reasons, such as significant side effects or acute illness, were included. As part of routine care, patients were invited to complete lung cancer-specific ePROMs, comprising 14 symptom items adapted from CTCAE v5.0, EQ-5D-5L, and EQ-VAS (0 = worst, 100 = best imaginable health). The most recent ePROMs completed within eight weeks before the start of radiotherapy were analysed. Data analysis followed the PROGRESS framework for overall prognosis research to compare pre-treatment ePROMs between patients with and without interruptions [2]. Results: Results: Over three years,526 patients underwent curative-intent thoracic therapy and completed pre- treatment ePROMs. Fourteen (2.6%) experienced unplanned treatment interruptions due to medical reasons, and two (0.4%) discontinued treatment early. Table 1 summarises reported symptoms and quality- of-life outcomes for patients with interruptions for medical reasons (n = 14) and those without (n = 512). Recognising the difference in group sizes, patients with unplanned interruptions more frequently reported dyspnoea (79% vs 61%), fatigue (79% vs 65%), and pain (64% vs 37%), alongside worse EQ-5D mobility (86% vs 57%), usual activities (82% vs 57%), and pain/discomfort (71% vs 49%) before radiotherapy. Median EQ-VAS score was lower in the interruption group (67.5 vs 75). Table 1. Comparison of pre-treatment ePROMs between patients with unplanned radiotherapy interruptions due to medical reasons and those without interruptions.
engage with the application at 3 months showed a potentially clinically meaningful improvement in HRQOL post radiotherapy. Feasibility challenges exist in integrating ePROs for metastatic cancer patients receiving RT with low engagement and declining compliance found. Incorporating patient feedback, addressing application usability issues and provider engagement may improve future implementation. References: 1. Health Service Executive. The development of radiation oncology services in Ireland: An analysis of models as applied to Ireland. Irish Department of Health and Children; 2003.2. Klein J, Livergant J, Ringash J. Health-related quality of life in head and neck cancer treated with radiation therapy with or without chemotherapy: A systematic review. Oral Oncol. 2014;50(4):254–62.3. Scott NW, Fayers PM, Aaronson NK, Bottomley A, de Graeff A, Groenvold M, Gundy C, Koller M, Petersen MA, Sprangers MAG, The EORTC Quality of Life Group. EORTC QLQ-C30 Reference Values Manual. Brussels: European Organisation for Research and Treatment of Cancer; 2008. Keywords: ePROs, feasibility, metastatic disease Digital Poster 3338 Radiotherapy interruptions in lung cancer: insights from patient-reported outcomes Anna Chrimes 1,2 , Thitikorn Nuamek 1 , Paul Hoey 3 , James Price 1,2 , Corinne Faivre-Finn 1,2 1 Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom. 2 Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom. 3 Clincal outcome and Data unit, The Christie NHS Foundation Trust, Manchester, United Kingdom Purpose/Objective: Curative-intent radiotherapy for lung cancer should ideally be delivered without interruption, as unplanned breaks in lung cancer treatment can compromise local control and outcomes [1]. With electronic patient-reported outcome measures (ePROMs) increasingly adopted into routine oncology practice for symptom monitoring, this study explored unplanned radiotherapy interruptions lung radiotherapy and assessed whether pre-treatment ePROMs could identify patients at risk. Material/Methods: Adult patients with small cell or non-small cell lung cancer who received curative-intent thoracic radiotherapy between July 2022 and July 2025 were included. Demographic and clinical data were retrieved from structured electronic patient record and radiotherapy planning systems. Interruptions
Conclusion: Unplanned radiotherapy interruptions were uncommon and primarily due to medical reasons. Patients who experienced interruptions reported worse pre-treatment symptoms and quality-of-life. Although limited by small numbers, these findings warrant validation in larger prospective studies.
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