S1434
Interdisciplinary - Other
ESTRO 2026
2 Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Chengdu, China
Digital Poster Highlight 1378
Purpose/Objective: The clinical translation of FLASH radiotherapy (FLASH- RT) is critically constrained by the lack of dosimetry tools capable of direct, real-time measurement within the living body. This fundamental gap prevents the precise correlation of the unique physical parameters of FLASH beams with the profound normal tissue sparing effects observed. To address this unmet need, we developed and validated a pioneering, miniaturized, and implantable wireless dosimeter, designed to provide gold-standard, real-time dose verification in the target volume and surrounding healthy tissues during FLASH-RT. Material/Methods: We engineered a biocompatible, miniaturized dosimeter based on a proprietary circuit architecture, enabling seamless implantation and real-time data transmission. Its performance was rigorously characterized in vitro under ultra-high dose rate irradiation. The definitive in vivo functionality and accuracy were then assessed by implanting the device in murine models undergoing FLASH-RT, capturing dose deposition dynamics within the local tissue microenvironment. Results: The dosimeter exhibited outstanding performance, demonstrating a linear response (R² = 0.984) to the external beam dose in vitro. Successful in vivo implantation confirmed the device's capability to provide stable and real-time dose readings. This technology successfully captured high-fidelity, millimetric-resolution data, directly linking the physical dose deposition to the subsequent biological response - a critical prerequisite for elucidating the FLASH effect. Conclusion: This work presents a novel implantable wireless dosimeter that innovates the paradigm of treatment verification for FLASH-RT. By providing the first direct, real-time link between physical dose and biological outcome in vivo, this tool is poised to de-risk and accelerate the safe clinical translation of this transformative radiotherapy technique. References: [1] Hou, B., Yi, L., Hu, D. et al. A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy. Nat. Biomed. Eng 7, 1242–1251 (2023). https://doi.org/10.1038/s41551-023-01024-2.[2] Scarantino, C.W., Ruslander, D.M., Rini, C.J., Mann, G.G., Nagle, H.T. and Black, R.D. (2004), An implantable radiation dosimeter for use in external beam radiation therapy. Med. Phys., 31: 2658- 2671. https://doi.org/10.1118/1.1778809. Keywords: FLASH RT, In vivo dosimetry, Implantable Device
How to establish the framework for an ESTRO focus group: An example of the Reirradiation group Daniella Elisabet Østergaard 1 , Laure Marignol 2 , Wolfgang Lechner 3 , Aileen Dufton 4 , Eliana Vasquez Osorio 5 , Stefanie Corradini 6 , Ane Appelt 1,7 , Nicolaus Andratschke 8 1 Department of Oncology, University Hospital of Copenhagen – Rigshospitalet, Copenhagen, Denmark. 2 Trinity St. James's Cancer Institute, Radiobiology and Molecular Oncology Research Group, Ap-plied Radiation Therapy Trinity, Discipline of Radiation Therapy, Trinity College, Dublin, Ireland. 3 Department of Radiation Oncology, Division of Medical Physics, Medical University Vienna, Vienna, Austria. 4 The Beatson West of Scotland Cancer Centre, Glasgow, UK & Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom. 5 Division of Cancer Sciences, The University of Manchester, The Christie NHS Foundation Trust, Manchester, United Kingdom. 6 Department of Radiation Oncology, LMU Munich, Munich, Germany. 7 Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark. 8 Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland Purpose/Objective: The strategic vision for ESTRO 2024-2026 highlighted member engagement as a major take-away(1); and the newly established entity of ESTRO focus groups (FG) play a key role here. While ESTRO provided guidance on the formal process of establishing a FG, the newly established FG Reirradiation was faced with the challenge of integrating ongoing activities while developing new perspectives within a transversal multi-professional group. Organizing and aligning such a diverse and engaged group of academic experts can – without shared structure – at times resemble ‘herding cats’. Therefore, the aim of this work was to apply and report a structured, systematic and inclusive process to build a shared vision, establish clear objectives, and ensure strong governance. Material/Methods: This work was centred around a workshop conducted during ESTRO congress 2025 and is positioned within the overall FG process (Figure 1). It included a systematic exploration of four predefined questions using a brain-writing exercise, exploring participants’ vision, purpose, engagement, and operational preferences. Answers were transcribed and used for thematic analysis to identify primary and secondary themes. These were subsequently evaluated through a SWOT analysis and Porter’s Five Forces framework.
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