S1438
Interdisciplinary - Other
ESTRO 2026
radiotherapy in breast cancer patients: a multicentric prospective real-life data farming analysis. Radiat Oncol. 2022 Apr 20;17(1):80. doi: 10.1186/s13014-022- 02044-z.2. Giraud P, Guihard S, Thureau S, Guilbert P, Ruffier A, Eugene R, Lamrani-Ghaouti A, Chargari C, Liem X, Bibault JE. Prediction of the need of enteral nutrition during radiation therapy for head and neck cancers. Radiother Oncol. 2025 Feb;203:110693. doi: 10.1016/j.radonc.2024.110693. Epub 2024 Dec 21. Keywords: Data farming, consultation, Real world data The SAFEST facility at Sapienza: accelerating electrons at VHEE in UHDR conditions and providing access to FLASH photon irradiations. Alberto Burattini 1,2 , Marina Carruezzo 2,3 , Enrica Chiadroni 2,4 , Alessandro Curcio 2,4 , Luca Egoriti 5,6 , Stefano Farina 2,7 , Gaia Franciosini 2,7 , Lucia Giuliano 2,7 , Alexander Gottberg 8,5 , Cornelia Hoehr 8,5 , Marco Magi 2,7 , Michela Marafini 9,2 , Mauro Migliorati 2,7 , Andrea Mostacci 2,7 , Luigi Palumbo 2,7 , Flaminia Quattrini 7,2 , Alessio Sarti 2,7 , Angelo Schiavi 2,7 , Marco Toppi 2,7 , Giacomo Traini 2 , Vincenzo Patera 2,7 Digital Poster 1716 1 Post-graduate School in Medical Physics, Sapienza University of Rome, Rome, Italy. 2 Department of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Rome, Italy. 3 National Center for Radiation Protection and Computational Physics, Italian National Institute of Health, Rome, Italy. 4 National Laboratories of Frascati, National Institute for Nuclear Physics (INFN), Frascati, Italy. 5 TRIUMF, Canada's Particle Accelerator Centre, Vancouver, Canada. 6 Chemistry, University of British Columbia, Vancouver, Canada. 7 Roma I Section, National Institute for Nuclear Physics (INFN), Roma, Italy. 8 Physics and Astronomy, University of Victoria, Victoria, Canada. 9 ,, “Enrico Fermi” Historical Museum of Physics and Study & Research Centre (CREF), Rome, Italy Purpose/Objective: The SAFEST (SApienza Flash Electron Source for radio- Therapy) project [1] at Sapienza University is developing a compact, hospital-compatible Very High- Energy Electron (VHEE) facility for FLASH radiotherapy. The main goal is to create a VHEE accelerator capable of reaching the high dose rates and high currents needed for Ultra High Dose Rate (UHDR) irradiations. The chosen technology is a compact C-band linear accelerator operating in the 5.712 GHz frequency range designed to deliver the ultra-high dose rates required for the FLASH effect, which can potentially spare healthy tissue and capable of delivering up to 200 mA of current. The design being constructed is shown in Figure 1. With a proper converter, like the
one currently being developed at TRIUMF [2], such a machine can also deliver UHDR photons, for FLASH RT irradiations.
Figure 1.
Material/Methods: By means of FLUKA[3] MonteCarlo simulations, the SAFEST accelerator has been studied using as input the configurations that are relative to the first two machine commissioning phases (energies equal to 10 and 24 MeV respectively, in view of a last upgrade up to 100, 150 MeV) and an additional configuration in which a tantalum converter is inserted at the end of the beam line. The target configurations used have been a water phantom and a small animal (mouse). Different irradiation solutions have been explored as well: flat beam for flask irradiations and active beam scanning solutions for small animal and detector/dosimetry calibrations. Results: The dose distributions have been obtained, together with the dose rate distribution in the irradiation of water phantoms or small animals with electrons and photons (linac operating at 10 MeV). If available, the machine is still under construction, comparison against the collected data at 10 MeV will be shown. The impact of the machine operation in terms of radioprotection constraints will be discussed both in case of VHEE and UHDR photon irradiations. Conclusion: The SAFEST facility provides a foundational platform for the development of compact VHEE linear accelerators capable of achieving 100 MeV energies. The future clinical translation of VHEE linacs requires targeted research to address key implementation challenges. These include optimizing treatment planning systems (TPS) for FLASH delivery, establishing robust quality assurance protocols, and refining patient positioning and immobilization methods. Furthermore, extensive clinical trials are essential to ascertain the long-term radiobiological effects and clinical outcomes of VHEE-based FLASH radiotherapy. The SAFEST facility will be a fundamental resource for conducting such crucial investigations. References: [1] A compact C-band FLASH electron linear accelerator prototype for the VHEE SAFEST project, Front.
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