S1481
Interdisciplinary - Patient involvement
ESTRO 2026
clinical care. It demonstrates how embedding the patient voice drives meaningful service improvements and equitable access to advanced radiotherapy. References: Keywords proton beam treatment/therapy; care coordination; patient support Keywords: proton, care coordination, patient support
systemic vascular resistance index (SVRi), and peak-HR SV (all P < 0.05). Conventional echocardiographic measures (ejection fraction, left ventricular dimensions) and serum biomarkers (cTnI, BNP) showed no significant changes. With a median follow- up of 24.2 months, the 18-month adjusted incidence of grade ≥2 cardiotoxicity was 12.6%. Lower baseline rest SV (OR = 0.918, P = 0.001), higher baseline BNP (OR = 1.033, P = 0.001), and higher mean heart dose (OR = 1.132, P = 0.003) independently predicted cardiotoxicity. A risk model based on these variables stratified patients into low- and high-risk groups with 18-month event rates of 3.7% vs. 35.7% (P < 0.001). The 18-month PFS rate was 56.0% (95% CI: 49.0– 63.9%). Tumor stage, ISH score, and pre-radiotherapy rest SV were independently associated with PFS. In the joint model, cumulative longitudinal rest SV was strongly associated with PFS (HR = 0.886, P < 0.001) and showed superior predictive performance compared with the static model (AUC 0.822 vs. 0.717). Conclusion: ICG-based longitudinal stroke volume monitoring offers a noninvasive and practical biomarker to improve prediction of both cardiac toxicity and PFS in LA-NSCLC treated with CCRT and immunotherapy. This approach supports dynamic risk stratification and cardioprotective strategies in the era of multimodal therapy. Keywords: Lung cancer, Early prediction of Cardiac toxicity
Proffered Paper 2714
Impedance cardiography during a 6-minute walk test for early prediction of cardiac toxicity and outcomes in LA-NSCLC receiving CCRT and immunotherapy Pengxin Zhang 1 , Bo Qiu 1 , Yingqing Li 2 , Haoting Zhang 1 , Qiaoting Liu 1 , Yingjia Wu 1 , Mengru Wang 1 , Yu Situ 1 , Yaoling Dong 1 , Daquan Wang 1 , Hui Liu 1 , Mai Xiong 3 1 Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. 2 Emergency, Sun Yat-sen University Cancer Center, Guangzhou, China. 3 Cardiac Surgery, The First Affifiliated Hospital of Sun Yat-sen University, Guangzhou, China Purpose/Objective: To evaluate whether integrating hemodynamic parameters obtained from impedance cardiography during the 6-minute walk test (6MWT-ICG) with routine cardiac assessment enables earlier prediction of cardiac toxicity and progression-free survival(PFS) in patients with locally advanced non-small cell lung cancer (LA-NSCLC) undergoing concurrent chemoradiotherapy (CCRT) and immunotherapy. Material/Methods: In this longitudinal cohort study (NCT06277388), 231 patients with unresectable stage IIIA–IIIC NSCLC received induction chemo-immunotherapy followed by CCRT and consolidative immunotherapy. Serial cardiac assessments—including 6MWT-ICG, echocardiography, cardiac ultrasound, and serum cardiac biomarkers—were performed at four time points from baseline to 2 months after completion of CCRT. Longitudinal cardiac parameter changes were analyzed using linear mixed-effects models. The cumulative incidence of grade ≥2 cardiac events was estimated with non-cardiac death considered as a competing risk. Univariable and multivariable Cox proportional hazards models were applied to evaluate the effects of cardiac parameters, along with patient- and treatment-related factors, on the risk of cardiac events. Both static and joint Cox proportional hazards models were subsequently used to assess associations between these variables and PFS. Results: Significant dynamic changes occurred across multiple ICG parameters, including rest stroke volume (SV), cardiac output (CO), left cardiac work index (LCWi),
Proffered Paper 3269
From patient to partner: bridging the divide through a “Dragon’s Den” style model of co- creation in cancer research Ashwini Job 1 , Beverly Agass 1 , Neil G Burnet 1 , Helene Judge 1 , Andrew Land 1 , Hilary Stobart 1 , Amy Tang 1 , Nicola Le Blond 2 , Charlotte E Coles 2 1 Radiotherapy Research Patient and Public Involvement and Engagement Group, University of Cambridge, Cambridge, United Kingdom. 2 Department of Oncology, University of Cambridge, Cambridge, United Kingdom Purpose/Objective: Cancer research is evolving - from being conducted for patients to creation with them. The Radiotherapy Research Patient and Public Involvement and Engagement (PPIE) group supporting radiation research at Cambridge has adapted the format used in a popular UK TV programme to develop a “Dragon’s Den” 1 model. It provides a platform for patient peer challenge and places lived experience at the heart of research. It aims to break down barriers between
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