S1482
Interdisciplinary - Patient involvement
ESTRO 2026
researchers and patients and develop a co-creation pathway to improve cancer research. A particular focus is to address the unmet need of embedding PPIE within pre-clinical studies2. Material/Methods: The initial event in the style of “Dragon’s Den” 1 in May 2025 invited four research teams to present proposals (ranging from discovery radiation science to clinical- translational research) to a diverse radiotherapy PPIE panel. Each presentation was followed by an open dialogue where the panel offered feedback on study design, communication and the realities of treatment burden. A second event in September 2025, repeated this process with a new cohort of researchers. A third event is planned for 2026, where all researchers will present on how early patient involvement has shaped their projects, the impact it’s had and their plans for embedding patient feedback in future work. These reflections will inform and refine the model for future cycles. Results: This approach provided a low-effort, high-impact method of embedding patient involvement early in research. 6/8 proposals were pre-clinical radiation studies. Qualitative results from free-text researcher feedback described it as “insightful” with a “supportive but positively challenging environment” that “outperformed expectations”. PPIE members reported feeling valued and inspired by the research. Early data suggest that this approach has influenced lab-based and clinical/translational research protocols and grant applications and created a positive culture bridging the gap between patients and researchers. Impact results will be collated following the third event to present at ESTRO 2026. Development of a transferable practical toolkit is planned to enable others to implement this approach. Conclusion: This initiative demonstrates that by uniting patient voices with scientific expertise, research can be transformed to genuine co-creation. This includes a pioneering approach in Cambridge to embed PPIE within pre-clinical research. Use of this novel and transferable methodology enables the real power of PPIE - not just providing opinions at the end of a project, but being involved early, whereby PPIE voices shape how research is designed, communicated, and delivered. References: 1. Dragon’s Den. BBC Studios Factual Entertainment Productions, 2005-present.2. Shaw KL et al. Integrating patient and public involvement and engagement in translational medicine. Lancet. 2024 Aug 31;404(10455):828-831.AcknowledgmentsThe Radiotherapy Research PPIE Group is supported by the National Institute for Health and Care Research (NIHR) and partners with Cancer Research UK RadNet
Cambridge. Keywords: Patient, involvement, research
Poster Discussion 3421 Patient and healthcare professional perspectives on health-related quality of life in bone metastases: an international comparative study Britney Zhang 1 , Shely Kagan 1 , Christina Yang 1 , Shivani Verma 1 , Sarah Bayrakdarian 1 , Caroline Hircock 2 , Hany Soliman 1 , Henry CY Wong 3 , Agata Rembielak 4,5 , Adrian W Chan 6 , Balamurugan A Vellayappan 7,8 , Dirk Rades 9 , Ali Alkan 10 , Pierluigi Bonomo 11 , Michele Aquilano 12 , Gustavo N Marta 13,14 , Daniel de Sousa Miragaia de Oliveira 13 , Vassilios Vassiliou 15 , Morfo Georgiou 15 , Vassilis Kouloulias 16 , Zoi Liakouli 16 , Edward Chow 1,2 , Shing Fung Lee 7,8 1 Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada. 2 Department of Medicine, University of Toronto, Toronto, Canada. 3 Department of Oncology, Princess Margaret Hospital, Kowloon West Cluster, Hong Kong S.A.R, China. 4 Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom. 5 Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom. 6 Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, Canada. 7 Department of Radiation Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore. 8 Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore. 9 Department of Radiation Oncology, University of Lübeck, Lübeck, Germany. 10 Department of Medical Oncology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Turkey. 11 Department of Radiation Oncology,, Azienda Ospedaliero- Universitaria Careggi, Florence, Italy. 12 Centro di Radiochirurgia Cyberknife IFCA, Casa di Cura Villa Ulivella e Glicini, Florence, Italy. 13 Department of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil. 14 Postgraduate Program, Department of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. 15 Department of Radiation Oncology, Bank of Cyprus Oncology Centre, Nicosia, Cyprus. 16 Department of Clinical Radiation Oncology, Medical School, National and Kapodistrian University of Athens, ATTIKON University Hospital, Athens, Greece Purpose/Objective: Advances in radiotherapy, systemic therapy, and supportive care have reshaped the health-related quality of life (HRQoL) priorities of patients with bone metastases (BM), highlighting the need to re-evaluate
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