S1483
Interdisciplinary - Patient involvement
ESTRO 2026
existing HRQoL measures. Phase I of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-Bone Metastases 22 (BM22) module update aimed to identify contemporary HRQoL issues considered important by patients and healthcare professionals (HCPs). This study compared their perspectives to ensure the forthcoming module remains comprehensive and patient-centred. Material/Methods: New HRQoL issues were identified through a systematic review and interviews with HCPs and patients across seven countries. Both groups rated each issue’s relevance (1 = “not at all” to 4 = “very much”), indicated whether it should be included, and ranked the ten issues they considered most important. Individual Top-10 rankings were converted to numerical scores (rank 1 = 10 points to rank 10 = 1 point) and summed to generate total Top-10 scores. Issues were also ranked by Top-10 frequency and mean relevance scores (average 1–4 ratings). Standard competition ranking was applied, and rank differences (Δrank = HCP − patient) were calculated across all three approaches to assess agreement. Results:
and pain flare (emphasised by HCPs) versus weight changes (emphasised by patients). Despite overall concordance, some issues showed variable Δrank values between methods, including limitations in using public transportation, lack of motivation, relationships with family and friends affected by BM, limping when walking, painful swelling or mass, and interference with sexual activity. Conclusion: HCPs and patients showed broad alignment regarding pain and functional limitations but differed in emphasis – HCPs prioritised symptoms, while patients highlighted psychosocial and daily functioning aspects. These findings support integrating both perspectives to ensure that the updated EORTC QLQ-BM22 module reflects the contemporary patient experience. Keywords: Bone metastases; HRQoL; EORTC QLQ- BM22; PROs
Digital Poster Highlight 3703 Identifying the top 10 quality of life concerns in
keratinocyte carcinoma: perspective of international patients and healthcare professionals
Shely Kagan 1 , Britney Zhang 1 , Christina Yang 1 , Shivani Verma 1 , Sarah Bayrakdarian 1 , Caroline Hircock 2 , Shing Fung Lee 3,4 , Henry CY Wong 5 , Adrian W Chan 6 , Adam Chichel 7 , Vassilios Vassiliou 8 , Gustavo N Marta 9,10 , Daniel de Sousa Miragaia de Oliveira 9 , Satoshi Hirakawa 11 , Romaana Mir 12 , Tara Chalk 12 , Elizabeth A Barnes 1 , Pierluigi Bonomo 13 , Panagiotis Kapsalis 14 , Vassilis Kouloulias 14 , Edward Chow 1 , Agata Rembielak 15,16 1 Department of Radiation Oncology, Odette Cancer Centre, Toronto, Canada. 2 Department of Medicine, University of Toronto, Toronto, Canada. 3 Department of Radiation Oncology, National University Hospital, Singapore, Singapore. 4 Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore. 5 Department of Oncology, Princess Margaret Hospital, Hong Kong S.A.R., China. 6 Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, Canada. 7 Brachytherapy Department, Greater Poland Cancer Centre, Poznan, Poland. 8 Department of Radiation Oncology, Bank of Cyprus Group Oncology Centre, Nicosia, Cyprus. 9 Department of Radiation Oncology, Hospital Sírio-Libanês, Sao Paulo, Brazil. 10 Department of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil. 11 Department of Supportive Care in Cancer, Seirei Hamamatsu General Hospital, Hamamatsu, Japan. 12 Mount Vernon Cancer Centre, East and North Hertfordshire Teaching NHS Trust, Northwood, United Kingdom. 13 Department of Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence,
Eight issues appeared in both Top-10 lists: neuropathic pain, breakthrough pain, weakness of limbs, limitation in range of motion, head and neck pain, need for walking aids, feeling helpless or desperate, and difficulty completing tasks (Table 1). HCPs additionally prioritised sensory changes and cranial nerve symptoms, while patients highlighted interference with recreational activities and worry about falls or fractures. Consistent prioritisation (Δrank <5) across all three ranking methods was seen for head and neck pain, weakness of limbs, feeling helpless or desperate, treatment-related oral side effects, time commitment of treatment, and limb swelling. Large discrepancies (Δrank ≥10) were observed for cranial nerve symptoms
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