S1484
Interdisciplinary - Patient involvement
ESTRO 2026
Italy. 14 Radiotherapy Unit, National and Kapodistrian University of Athens, Athens, Greece. 15 Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom. 16 Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom Purpose/Objective: Keratinocyte carcinoma (KC), including basal and skin squamous cell carcinoma, is the most common malignancy worldwide. While prognosis is generally favourable, KC can significantly impair health-related quality of life (HRQoL) through physical symptoms, cosmetic changes, and psychosocial distress. Existing HRQoL instruments do not fully capture these disease- specific effects. Phase I of the European Organisation for Research and Treatment of Cancer (EORTC) KC module development aimed to identify and prioritize KC-specific HRQoL concerns from both patient and healthcare professional (HCP) perspectives to inform the forthcoming EORTC KC module. Material/Methods: A systematic literature review identified potential HRQoL issues, refined through semi-structured interviews with 63 HCPs from eight countries. HCPs rated 49 items on a 4-point Likert scale for relevance and provided qualitative feedback; one additional item (“skin itchiness/burning sensation”) was added, yielding 50 issues. These were subsequently evaluated by 93 patients from eight countries, who rated importance, indicated inclusion and selected their ten most important concerns. Weighted scoring (rank 1=10 points to rank 10=1 point) generated cumulative Top-10 scores. Rankings were analysed using mean relevance, Top-10 frequency and standard competition ranking with rank differences (Δrank= HCP−patient) used to assess concordance. Results: Nineteen KC-specific issues were evaluated for Top-10 inclusion. Eight appeared in both patient and HCP lists: pain at the lesion site, delayed healing, visible scarring, irritation, dryness, fear of recurrence, anxiety and limitations in daily activities. HCPs also prioritized ulceration, movement restriction and treatment discomfort. Patients emphasized appearance, social interaction and emotional coping. Across all ranking methods, consistent prioritization (Δrank < 5) was seen for atrophy of skin, anger, low energy, fear of treatment, muscle spasms, weight gain, and weight loss. Larger discrepancies (Δrank ≥ 10) were seen for issues HCPs prioritized more than patients, including hair loss, infection, pain from scars, functional limitations, nerve damage, self-consciousness, public/social discomfort, poor follow-up care and mouth changes. Issues patients prioritized more than HCPs included skin dryness, checking for lumps, worry about family, causes of skin cancer, sun safety, telling
others to protect themselves and concern about worrying friends/family. Despite overall concordance, some issues (atrophy, fibrosis, skin rash, ulceration) showed variable Δrank depending on the scoring method.
Conclusion: Phase I of the EORTC KC module development identified key KC-specific HRQoL concerns valued by both patients and HCPs. These findings underscore the importance of incorporating both perspectives to ensure the forthcoming EORTC KC module accurately reflects the most relevant impacts of KC on patients’ lives. References: Kennedy SKF, Lee SF, Zhang E, et al. Quality of life issues faced by patients with keratinocyte cancer: a systematic review. EJC Skin Cancer. 2024;2:100022. Keywords: QoL, patient reported outcomes, skin cancer Digital Poster 3780 Phase I EORTC module development for keratinocyte carcinoma: patients and healthcare professionals survey Shely Kagan 1 , Britney Zhang 1 , Christina Yang 1 , Shivani Verma 1 , Sarah Bayrakdarian 1 , Caroline Hircock 2 , Paula Tur 3 , Shing Fung Lee 4,5 , Henry C Y Wong 6 , Adrian W Chan 7 , Adam Chichel 8 , Vassilios Vassiliou 9 , Gustavo N Marta 10,11 , Daniel de Sousa Miragaia de Oliveira 10 , Satoshi Hirakawa 12 , Romaana Mir 13 , Tara Chalk 13 , Elizabeth A Barnes 1 , Pierluigi Bonomo 14 , Panagiotis Kapsalis 15 , Vassilis Kouloulias 15 , Edward Chow 1 , Agata Rembielak 16,17
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