S1485
Interdisciplinary - Patient involvement
ESTRO 2026
1 Department of Radiation Oncology, Odette Cancer Centre, Toronto, Canada. 2 Department of Medicine, University of Toronto, Toronto, Canada. 3 Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle-upon-Tyne, United Kingdom. 4 Department of Radiation Oncology, National University Hospital, Singapore, Singapore. 5 Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 6 Department of Oncology, Princess Margaret Hospital, Hong Kong S.A.R, China. 7 Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, Canada. 8 Brachytherapy Department, Greater Poland Cancer Centre, Poznan, Poland. 9 Department of Radiation Oncology, Bank of Cyprus Group Oncology Centre, Nicosia, Cyprus. 10 Department of Radiation Oncology, Hospital Sírio-Libanês, Sao Paulo, Brazil. 11 Department of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil. 12 Department of Supportive Care in Cancer, Seirei Hamamatsu General Hospital, Hamamatsu, Japan. 13 Mount Vernon Cancer Centre, East and North Hertfordshire Teaching NHS Trust, Northwood, United Kingdom. 14 Department of Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. 15 Department of Clinical Radiation Oncology, National and Kapodistrian University of Athens, Athens, Greece. 16 Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom. 17 Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom Purpose/Objective: Keratinocyte carcinoma (KC), comprising basal cell carcinoma and skin squamous cell carcinoma, is the most common skin malignancy globally. Although rarely life-threatening, KC can substantially impair quality of life (QoL) through pain, visible disfigurement, functional limitations and psychosocial distress. Generic cancer QoL instruments, such as the EORTC QLQ-C30, do not adequately capture KC-specific issues. This Phase I study aimed to identify and prioritize KC-relevant QoL issues to inform development of a disease-specific EORTC module. Material/Methods: Following EORTC Quality of Life Group guidelines, a systematic literature review identified candidate health-related QoL (HRQoL) issues for KC. 63 healthcare professionals (HCPs) from eight countries and multiple disciplines, including oncology, nursing, radiation therapy, and allied health, evaluated 49 issues using a 4-point Likert scale and qualitative feedback. Based on their input, one additional item “skin itchiness/burning sensation” was added, yielding 50 issues for patient evaluation. These were assessed by 93 patients with KC across eight countries,
representing diverse demographics, disease stages, lesion sites and treatment modalities. Patients rated relevance, voted for inclusion/exclusion, and ranked the top ten issues. Results: Both patients and HCPs prioritized physical symptoms (ulceration, slow healing, skin irritation, itchiness/burning), cosmetic and functional concerns (scarring, dryness, activity limitation), psychological impacts (anxiety, fear of recurrence) and behavioural adaptations (sun protection, lifestyle changes). Patients emphasized emotional and social impacts, including self-consciousness and activity limitations, while HCPs highlighted chronic effects such as infection risk and delayed healing. HCPs had mean relevance scores ranging from 2.0-3.7, prevalence exceeding 70.0% for most issues, and priority rankings between 1.6-57.1%. Participants represented diverse professions, including physicians (46.0%), radiation therapists (22.2%), nurses (23.8%), and allied health professionals (8.0%). Patient mean relevance scores ranged from 0.7-2.9, prevalence 60.0-80.0%, and priority votes 30.0-70.0%. Nineteen issues met ≥3 of 4 predefined thresholds (mean relevance, prevalence, priority, top-10 ranking) and were selected for Phase II. The final set reflects the multidimensional impact of KC, integrating symptom burden, emotional well-being and lifestyle considerations. Conclusion: Phase I of this study identified 19 core KC-specific QoL issues from an initial 50-item pool, providing a robust, patient-centered foundation for the EORTC KC module. These findings emphasize the importance of capturing both physical and psychosocial consequences, as well as behavioural adaptations, to enhance patient-cantered care, guide clinical decision- making and support future research in KC. References: Kennedy SKF, Lee SF, Zhang E, et al. Quality of life issues faced by patients with keratinocyte cancer: a systematic review. EJC Skin Cancer. 2024;2:100022. Keywords: QoL, patient reported outcomes, skin cancer Digital Poster Highlight 4235 Concordance of healthcare professional and patient evaluations of the most important quality of life issues in patients with ductal carcinoma in situ Christina Yang 1 , Shivani Verma 1 , Britney Zhang 1 , Shely Kagan 1 , Sarah Bayrakdarian 1 , Caroline Hircock 2 , Shing Fung Lee 3,4 , Agata Rembielak 5,6 , Juan I Arraras 7 , Vesna Bjelic-Radisic 8 , Panagiotis Kapsalis 9 , Yuichiro Kikawa 10 , Vasileios Kouloulias 9 , Gustavo N Marta 11,12 , Nora Nevries 8 , Mami Ogita 13 , Daniel de Sousa Miragaia de
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