S295
Clinical - Breast
ESTRO 2026
particularly in Latin American regions where MBC remains underreported.ObjectiveTo describe and evaluate the epidemiologic, clinical, pathological, and treatment characteristics of male breast cancer patients managed at a third-level care center in northeastern Mexico between 2012 and 2022. Material/Methods: Materials and MethodsA retrospective, descriptive study was conducted, including male patients diagnosed with breast cancer at a third-level oncology institution in northeastern Mexico over 10 years (2012–2022). Data were extracted from the institutional cancer registry and clinical records. Variables collected included sociodemographic information, risk factors, TNM stage at diagnosis, histologic subtype, molecular classification, presence of lymphovascular invasion, treatment modalities (surgery, chemotherapy, hormone therapy, radiotherapy, targeted therapy), and follow-up information. Descriptive statistics were performed to analyze the frequency distribution and central tendency. Results: ResultsSeventeen male breast cancer patients were analyzed, with a median age of 70 years. Tumors were evenly distributed between the right and left sides. Most patients presented with stage IIA–IIB disease, with T2 and N0 as the predominant TNM categories. The luminal A/B subtype was the most common, observed in 82.4% of cases, while lymphovascular invasion was present in 70.5%. Modified radical mastectomy with axillary dissection was the primary surgical approach, whereas systemic chemotherapy and hormonal therapy were given to 82.4% and 53% of patients, respectively. General patient characteristics are summarized in Table 1.During follow-up, disease progression occurred in 29.4% of cases. Ten-year overall survival was 58.8%, and disease-specific mortality was 35.3%. Advanced clinical stage, lymphovascular invasion, high histologic grade, and triple-negative subtype were linked to worse outcomes. Conversely, patients with luminal subtypes and those on hormonal therapy showed improved survival rates.
Conclusion: ConclusionMale breast cancer showed predominantly luminal biology but frequent lymphovascular invasion, suggesting biologically aggressive disease. Prognostic
Made with FlippingBook - Share PDF online