S296
Clinical - Breast
ESTRO 2026
500 patients with a minimum follow-up of 4 years were analysed Results: RNRT was delivered to 365/500 patients (73%). Questionnaire return rates were 74% (n = 372), 64% (n = 320), and 46% (n = 228) at 6, 12, and 18 months, respectively. Estimated QL score following RNRT at 12 months (ultrahypofractionated versus standard) were 72.3 (95% CI, 69.1-75.4) and 72.1 (95% CI, 67.4-76.8), respectively. Model results for other functional scales are presented in Table 1. Figure 1 illustrates the trajectories of the scores in FACT-BCS, FACT-G and FACT-TOI at different time points. At none of these time points were scores meaningfully lower following RNRT. Similarly at 18 months post RNRT the proportion reporting “quite a bit” or “very much” swelling/tenderness in the arm was 12.8%versus 5.5% (Standard vs Ultrahypofractionation ).
evaluation of lymphovascular invasion, molecular subtype, and clinical stage may help guide individualized management and improve survival outcomes. Fentiman, I. S., Fourquet, A., & Hortobagyi, G. N. (2006). Male breast cancer. The Lancet, 367(9510), 595–604.2. Giordano, S. H. (2018). Breast cancer in men. New England Journal of Medicine, 378, 2311–2320.3. Abdelwahab Yousef AJ. Male breast cancer: Epidemiology and risk factors. Semin Oncol. 2017;44(5):267-272.4. Gómez- References: References1. Raposo, C., Zambrana Tévar, F., Sereno Moyano, M., López Gómez, M., & Casado, E. (2010). Male breast cancer. Cancer Treatment Reviews, 36(6), 451–457.5. Yadav S, Karam D, Bin Riaz I, Xie H, Durani U, Duma N, et al. Male breast cancer in the United States: Treatment patterns and prognostic factors in the 21st century. Cancer. 2020;126(1):26-36 Keywords: Male Breast Cancer Comparing Quality of Life (QOL) after adjuvant breast regional nodal radiotherapy (RNRT) within HYPORT Adjuvant trial (NCT03788213). Sanjoy Chatterjee 1 , Santam Chakraborty 1 , Rosina Ahmed 2 , Patricia S 3 , Rajesh Balakrishnan 4 , Selvamani B 5 , Punita Lal 6 , Shagun Mishra 6 , Shirley Lewis 7 1 Radiation Oncology, Tata Medical Center, Kolkata, India. 2 Surgical Oncology, Tata Medical Center, Kolkata, India. 3 Radiation Oncology, Christian Medical College, Velloreedical Center, Vellore, India. 4 Radiation Oncology, Christian Medical College, Vellore, Vellore, India. 5 Radiation Oncology, Christian Medical College, Vellore, Kolkata, India. 6 Radiation Oncology, SGPGI Lucknow, Lucknow, India. 7 Radiation Oncology, Kasturba Medical College, Manipal, India Proffered Paper 3286
Figure 1:Model-derived estimates of mean FACT BCS, FACT TOI, FACT G and FACT B scales. The red line represents the model-estimated means. Plots are faceted by randomisation group (columns) and Regional nodal Radiotherapy (rows). Higher scores indicate a better quality of life.Table 1: Model-derived coefficients for EORTC global QOL and functional scales . Positive coefficients indicate a better QOL (Bold- statistically significant).ScaleRandomisation Group (Experimental)Regional Nodal Radiotherapy (Yes)Coefficient 95% CICoefficient95% CIGlobal Quality of Life5.900.80 - 11.001.10-3.10 - 5.30Physical Functioning0.43-5.00 - 5.80-1.20-5.70 - 3.20Role Functioning0.87-4.50 - 6.300.38-4.10 - 4.80Emotional Functioning5.30-0.82 - 11.02.70-2.30 - 7.80Cognitive Functioning2.30-3.00 - 7.700.62-3.80 - 5.00Social Functioning 5.400.03 - 11.003.90-0.49 - 8.40 Conclusion: RNRT delivered using ultrahypofractionated radiotherapy, compared to standard, does not result in clinically meaningful declines in global or breast cancer-specific quality of life scale scores. Keywords: QOL, Ultrahypofractionation, RNRT
Purpose/Objective: HYPORT Adjuvant, a phase 3 randomised trial
recruited 2200 patients comparing the efficacy of an ultrahypofractionated (26 Gy in 5 fractions over 1 week) radiotherapy schedule to a standard moderately hypofractionated (40 Gy in 15 fractions over 3 weeks) schedule. We report the impact of RNRT on quality of life within the first 500 patients. Material/Methods: Patients completed the QoL evaluations (EORTC QLQ- C30 questionnaire and the FACT-B questionnaire) after randomisation, end of radiotherapy and 6, 12, 18 months post-radiotherapy. A linear mixed model with a random intercept was used to model all interactions. The randomisation group and the RT type (RNRT, yes vs. no) were modelled as fixed effects with an interaction with time (lme4 package). Data of the first
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