S351
Clinical - Breast
ESTRO 2026
However, Mepitel Film trended toward higher incidence of itchiness (10.8% vs 5.0%, p=0.11). Patient preference data were conflicting, with one trial favoring StrataXRT for ease of use and the other showing no clear preference. Conclusion: While StrataXRT and Mepitel Film demonstrated similar efficacy for preventing moist desquamation, Mepitel Film offered superior protection against grade 2 to 3 RD. However, this conclusion should be interpreted with caution given the underlying methodological limitations of the included studies. Keywords: Radiation dermatitis; Mepitel Film; StrataXRT Development of an expert-guided physiotherapy protocol for women undergoing adjuvant breast radiotherapy: a consensus-based normative synthesis Nara Fernanda Braz da Silva Leal 1 , Helcio Pandini Siqueira 2 , Hanaya Julia Medeiros Oliveira 3 , Francisco José de Queiroz Thomé 1 , Fernando Marin Torres 2 , Luciano de Souza Viana 4 , Ronaldo Cavalieri 5 , Alexandra Mussolino de Queiroz 6 , HARLEY FRANCISCO de OLIVEIRA 6,2 1 Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. 2 Centro de Tratamento em Radio-Oncologia, CTR, Ribeirão Preto, Brazil. 3 Faculty of Medicine of Marilia, FAMEMA, Marilia, Brazil. 4 Oncology Unit, Hospital Márcio Cunha, Ipatinga, Brazil. 5 Dep. de Radioterapia, Grupo IMNE e OncoBeda – Centro Integrado de Oncologia, Campos dos Goytacases (RJ), Brazil. 6 Department of Pediatric Dentistry,, University of São Paulo, Ribeirão Preto,, Brazil Purpose/Objective: Despite the progressive reduction in treatment-related morbidity achieved through sentinel lymph node biopsy and modern radiotherapy techniques (IMRT/IGRT), breast cancer patients remain at risk for upper-limb dysfunction, pain, and lymphedema. Digital Poster 5220 Although physiotherapy plays a key role in preserving function, no standardized protocol currently guides intervention during adjuvant radiotherapy. This study aimed to develop a structured, consensus-based physiotherapeutic protocol integrating scientific evidence and international expert judgment to ensure safety, reproducibility, and clinical feasibility. Material/Methods: A four-step methodological framework was adopted: (1) systematic review of randomized controlled trials on physiotherapy during RT (PubMed, Cochrane, PEDro, SciELO, BVS, CINAHL); (2) design of a structured
improved sparing of liver and lung tissue. Clin Transl Radiat Oncol. 2024;53:100660. doi:10.1016/j.ctro.2024.100660 Keywords: DIBH, dosimetry
Digital Poster 5190
Mepitel Film vs StrataXRT for Prevention of Radiation Dermatitis in Breast Cancer: A Systematic Review and Meta-analysis Henry C Y Wong 1 , Laura Tang 2 , Christina Yang 3 , Saverio Caini 4 , Shirley T W Tse 5,6 , Edward Chow 3 1 Department of Oncology, Princess Margaret Hospital, Lai Chi Kok, Hong Kong. 2 Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. 3 Department of Radiation Oncology, Odette Cancer Centre, Toronto, Canada. 4 Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. 5 Department of Clinical Oncology, Queen Elizabeth Hospital, Jordan, Hong Kong. 6 Department of Clinical Oncology, United Christian Hospital, Kwun Tong, Hong Kong Purpose/Objective: Radiation dermatitis (RD) affects up to 90% of patients receiving post-mastectomy radiotherapy, with moist desquamation causing significant morbidity. Barrier films and dressings such as Mepitel Film and StrataXRT have been shown to be effective compared to moisturizers, but their relative effectiveness remains debated. This systematic review and meta-analysis compares these interventions for preventing RD. Material/Methods: Following PRISMA guidelines, we systematically searched MEDLINE, Embase, and Cochrane Library through April 2025. Eligible studies were RCTs directly comparing StrataXRT and Mepitel Film in breast cancer patients receiving adjuvant radiation therapy. Two reviewers independently screened studies, extracted data, and assessed risk of bias using RoB 2.0. Meta- analysis used random-effects models to pool risk ratios (RR) for moist desquamation, and incidence of grade 2 and 3 RD, with I ² statistics quantifying heterogeneity. Results: From 33 screened records, two intra-patient, non- inferiority RCTs (n=120) met inclusion criteria. Both studies randomized medial/lateral chest wall halves to each intervention in post-mastectomy patients. Pooled analysis revealed no significant difference in moist desquamation incidence between StrataXRT (21.7%) and Mepitel Film (20.0%) (RR 1.03; 95% CI 0.52–2.04; p=0.93), with low heterogeneity (I ² =35%). Secondary outcomes showed Mepitel Film significantly reduced grade 2 or 3 RD (RR 1.34, 95% CI 1.10–1.64, p=0.004).
Made with FlippingBook - Share PDF online