S394
Clinical - CNS
ESTRO 2026
but also reduces associated symptoms, reinforces previous treatments and prevents new relapses and growth of the disease. Keywords: Schwannoma, Benign meningioma, Pituitary adenoma
methods) as well as treatment characteristics and outcomes, were analyzed. Results: A pool of 64 patients was studied: 36 schwannomas, 12 meningiomas, 12 pituitary adenomas and 4 craniopharyngiomas. All these patients were diagnosed using anamnesis and MRI, and 64% of them were treated on the first 6 months after their identification. 35 patients underwent surgery as initial management, later requiring radiotherapy due to symptom persistence or MRI-evidenced growth. All patients received radical radiotherapy. The predominant treatment techniques were Radiosurgery in schwannomas (83.3%), and Moderated Hypofractionation in meningiomas (75%), pituitary adenomas (58.33%) and craniopharyngiomas (75%). The most used treatment regimen was 25Gy/5fx (26.5%). Acute grade 1 toxicity occurred in 25 patients, being subsequently resolved. Tumor response was evaluated at 6 months, 2 years, and beyond 2 years of follow-up. A radiological and/or clinical response was observed both in the early and late periods in more than 50% of patients with pituitary adenomas and craniopharyngiomas. In meningiomas, an early response was documented in more than 50% of cases, although this effect was not maintained in the long- term follow-up. Conversely, vestibular schwannomas showed a late response in more than 50% of patients. (Table 1)Only 2 patients needed post-radiotherapy treatment: one meningioma (MRI finding >6 years post-RT, requiring radiotherapy) and one pituitary adenoma (MRI relapse >4 years post-RT, requiring surgery).
Proffered Paper 5028
Sodium-Copper-Chlorophyllin in the treatment of brain radionecrosis in adults with diffuse glioma: Interim results from the phase 2 CHROME study Archya Dasgupta 1 , Prachi Adole 1 , Abhishek Chatterjee 1 , Arpita Sahu 2 , Amitkumar Choudhari 2 , Ameya Puranik 3 , Indraja Dev 3 , Nandini Menon 4 , Epari Sridhar 5 , Vikram Gota 6 , Tejpal Gupta 1 1 Radiation Oncology, Tata Memorial Centre, Mumbai, India. 2 Radiodiagnosis, Tata Memorial Centre, Mumbai, India. 3 Nuclear Medicine, Tata Memorial Centre, Mumbai, India. 4 Medical Oncology, Tata Memorial Centre, Mumbai, India. 5 Pathology, Tata Memorial Centre, Mumbai, India. 6 Clinical Pharmacology, Tata Memorial Centre, Mumbai, India Purpose/Objective: Radionecrosis (RN) affects 5-15% of patients with diffuse gliomas. Definitive therapies for RN are corticosteroids and bevacizumab, which have their limitations. Sodium-copper-chlorophyllin (CHL) is a phytopharmaceutical agent demonstrated to act as an antioxidant and free radical scavenger in preclinical experiments, which can have potential effects in mitigating radiation-induced late effects. Material/Methods: The benefit of CHL in the treatment of RN is being investigated in the open-label, prospective, phase 2 interventional study (NCT06016452). Radionecrosis is identified using magnetic resonance imaging (MRI) with or without positron emission tomography (PET). Patients are accrued in two strata: symptomatic (stratum A) and asymptomatic (stratum B). Chlorophyllin is prescribed as a morning oral dose of 750 mg for 3 months. In addition, participants in stratum A receive a tapering dose of dexamethasone for 1 month. Patients undergo imaging at 1 month with MRI and PET, and MRI at 3 months. The primary endpoint of the study is combined radiological and clinical response at 1 month. The sample size is calculated using Simon's stage 2 design for each stratum, and here we present the interim results for both strata. Results: The scheduled response rate at 1 month for symptomatic RN is expected to be 65% with 29 responses (total sample size 60) and 45% for asymptomatic RN with 18 responses (sample size 58). As per protocol, an interim analysis was done after the
Conclusion: Radiotherapy is a safe and effective treatment for benign brain tumors. It not only decreases their size,
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