S395
Clinical - CNS
ESTRO 2026
Purpose/Objective: Central nervous system (CNS) tumours comprise a diverse spectrum of malignancies that demand multimodal management. Radiotherapy (RT) remains integral for curative, adjuvant, and palliative care. In sub-Saharan Africa, where data on CNS tumour management are sparse, understanding real-world treatment patterns is critical to guide system strengthening and align clinical practice with international standards. Material/Methods: We conducted a retrospective analysis of all adult (>18 years old) CNS tumour patients who received RT at the Medserve–LUTH Cancer Centre, Lagos, Nigeria, between January 2020 and December 2024. Electronic medical records were reviewed to extract demographic, pathologic, and treatment data, including diagnostic modalities, surgical and systemic therapy details, and RT parameters. Descriptive statistics were used to evaluate utilisation trends and patterns of care. Results: A total of 169 patients with CNS tumours were evaluated, of whom 127 (75.1%) received radiotherapy. The mean age was 47.1 years (range 21– 76), with most patients between 51–60 years (28.3%) and 41–50 years (26.0%). Females comprised 55.9% (n=71). The most common tumour types were glioblastoma (29.1%), astrocytoma (17.3%), and meningioma (18.9%). High-grade tumours predominated, with grade IV in 31.5% and grade III in 15.7%. Diagnosis was histologically confirmed in 85%, supported by imaging in the remainder; 101 patients (79.5%) underwent MRI prior to referral. Surgical intervention was performed in 112 patients (88.2%), and systemic therapy was administered to 65 (51.2%), predominantly temozolomide (96.9%). The intent of RT was radical or adjuvant in 117 patients (92.1%) and palliative in 10 (7.9%). Modern conformal techniques were widely employed; IMRT in 54.3% (n=69), VMAT in 22.0% (n=28), and 3DCRT in 23.6% (n=30). The most common fractionation schedules were 60 Gy in 30 fractions (38.6%) and 54 Gy in 30 fractions (18.1%). Overall, treatment completion was achieved in 113 patients (89.0%).
accrual of 55 patients (27 in stratum A and 28 in stratum B). Seven patients were considered to have progressive disease during accrual based on follow-up outcome and excluded from analysis for the primary endpoint as per protocol. Three patients were lost to follow-up, and 1 had died from sepsis, leading to 44 evaluable patients for primary endpoint analysis. A combined clinico-radiological response was achieved in 13 patients (62%) in stratum A and 14 patients (60%) in stratum B, and therefore, the study has proceeded to stage 2 for both strata based on predefined criteria. Compliance to medicine was well reported, with the majority of patients completing >95% of scheduled medications. Only side effect observed was transient diarrhoea in 3 patients, which had resolved spontaneously, and patients were able to resume the medication.
Conclusion: Chlorophyllin forms a well-tolerated oral medication that is being investigated in the ongoing study, with interim results demonstrating possible effectiveness in the treatment of RN. Keywords: Radionecrosis, Chlorophyllin, Glioma Digital Poster 5031 Radiotherapy Utilization in Central Nervous System Tumours: An Institutional Experience from sub-Saharan Africa adedayo Joseph 1,2 , Omotayo Ojo 3,4 , Bolanle Adegboyega 1,2 , Ayodeji Ojetunde 5 , Funmilayo Aina - Tolofari 1 1 Medserve - LUTH Cancer Centre, Lagos University Teaching Hospital, Lagos, Nigeria. 2 Department of Radiation Biology, Radiotherapy and Radiodiagnosis, College of Medicine, University of Lagos, Lagos, Nigeria. 3 Department of Surgery, College of Medicine, University of Lagos, Lagos, Nigeria. 4 Department of Surgery, Lagos University Teaching Hospital,, Lagos, Nigeria. 5 Medserve - LUTH Cancer Centre, Lagos University Teaching Hospital,, Lagos, Nigeria
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