S464
Clinical - Gynaecological
ESTRO 2026
https://seer.cancer.gov/statfacts/html/cervix. html Keywords: geriatric oncology, cervical cancer, QoL
Digital Poster 3115 Is Underweight a Risk Factor for Poor Prognosis in Cervical Cancer? Dunhuang Wang, Yimin Li Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, China Purpose/Objective: While obesity is an established risk factor for poor prognosis in cervical cancer, the impact of underweight remains inconclusive. Therefore, this study aims to investigate the association between underweight and survival outcomes in cervical cancer patients. Material/Methods: We conducted a retrospective analysis of 141 locally advanced cervical cancer patients who received concurrent chemoradiotherapy at our institution between June 2016 and December 2023. Clinical data included age, body mass index (BMI), body surface area (BSA), Nutritional Risk Screening (NRS) 2002 score, tumor size, histology, 2018 International Federation of Gynecology and Obstetrics (FIGO) stage, hemoglobin (HGB) level, and squamous cell carcinoma antigen (SCC) levels. Underweight is defined as a BMI of less than 18.5. Survival outcomes were analyzed using the Kaplan-Meier method, and variables with a P-value less than 0.1 in the univariate analysis were included in the multivariate Cox proportional hazards models. A P-value less than 0.05 indicates a statistically significant difference. Results: The median follow-up was 35 months (range, 6-106 months). For the 141 included patients with cervical cancer, the 3-year progression- free survival (PFS) and overall survival (OS) rates were 74.8% and 89.1%, respectively. In
Conclusion: Older women with cervical cancer
demonstrate a high prevalence of geriatric syndromes, particularly frailty, incontinence, sarcopenia, and cognitive impairment. Although no significant association with quality of life was identified, autos recognize the limitation os sample size of the study. Furthermore, the substantial burden observed supports routine geriatric screening to optimize clinical decision-making and improve functional outcomes. References: 1. Garcia, M. V., Agar, M. R., Soo, W.-K., To, T., Phillips, J. L., et al. (2021). Screening tools for identifying older adults with cancer who may benefit from geriatric assessment: A systematic review. JAMA Oncology, 7(4), 616– 627. https://doi.org/10.1001/jamaoncol.2020.6736 2. Kokawa, K., Takekida, S., Kamiura, S., Kita, M., Enomoto, T., Kawaguchi, R., et al. (2010). Incidence, treatment, and prognosis of cervical carcinoma in young women: Retrospective analysis of 4,975 cases in Japan. European Journal of Gynaecological Oncology, 31(1), 37–43.3. National Cancer Institute. (2025). SEER Cancer Stat Facts: Cervical cancer.
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