S469
Clinical - Gynaecological
ESTRO 2026
endometrioid adenocarcinoma/serous carcinoma/papillary serous carcinoma/clear cell/carcinosarcoma/mixed histology with the following AJCC 2009 grade/stage: Grade 2: stage IB (LVSI +/or >60 yrs), Grade 3: stage IA and IB, Grade 1-3: Stage II and IIIA, IIIB and IIIC1 who were staged with MRI or CT, had an ECOG performance status of 0–2, had surgery consisting of total hysterectomy, ± bilateral salpingo-oophorectomy, ± lymph node sampling and provided written informed consent. Quality of Life was evaluated using two European Organisation for Research and Treatment for Cancer (EORTC) questionnaires: QLQ C30 and QLQ CX24.This was an ICH-GCP-compliant prospective phase II trial, carried out in compliance with the Cancer Trials Ireland protocol, Good Clinical Practice Guidelines, and applicable ethical standards. Results: CTRIAL-IE 09-06 closed early due to concerns of futility: a trend to worse toxicity in the trial arm was observed. Of 92 patients accrued, 76 were evaluable for QOL outcomes.At baseline, there were no statistically significant differences in any QOL score between the two arms using both the EORTC QLQ C30 or EORTC QLQ CX24 questionnaires. During the final week of radiotherapy after adjustment for baseline scores, the IMRT arm was associated with a significantly better summary score (p= .029). Figure 1: EORTC QLQ C30 functioning and symptom scale
Conclusion: This randomised trial has demonstrated that the use of IMRT compared to 3D-CRT for locally advanced endometrial cancer may lead to improved QOL summary scores for patients at the end of radiotherapy. References: 1.Ferlay J, Ervik M, Lam, F, Laversanne M, Colombet M, Mery L, Pineros M, Znaor A, Soerjomataram I, Bray F (2024). Global Cancer Observatory: Cancer Today. Lyon, France: Intenational Agency for Research on Cancer. Available from: https://gco.iarc.who.int/media/globocan/fact sheets/cancers/24-corpus-uteri-fact- sheet.pdf2.https://www.ncri.ie/en/reports- publications/reports/cancer-trends-cancers- of-the-cervix-and-uterus3.Rossi S, Baili P, Capocaccia R, Caldora M, Carrani E, Minicozzi P, et al. The EUROCARE-5 study on cancer survival in Europe 1999-2007: Database, quality checks and statistical analysis methods. European Journal of Cancer. 2015 Oct 1; 51 (15):2104–19. Keywords: IMRT, Patient-reported outcomes, endometrial Digital Poster 3342 The Impact of Uterine Cancer on Conjugal Life : A study of a Tunisian Cohort Asma Ghorbel, Hajer Zelaiti, Semia Zarraa, Alia Mousli, Hadhemi Ayedi, Khadija Ben Zid, Najla Attia, Rim Abidi, Ameni Yousfi, Chiraz Nasr Radiotherapy, Salah Azaiez, Tunis, Tunisia
scores, at Baseline, Final week of Radiotherapy and six months post radiotherapy
Figure 2: EORTC QLQ 30 Summary score and Functioning scores at Final Week of Radiotherapy
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