S490
Clinical - Gynaecological
ESTRO 2026
failure and prognostic factor analyses in locally advanced cervical cancer patients staged by positron emission tomography and treated with curative intent. International Journal of Gynecological Cancer. 2009 Jul;19(5):912–8. Keywords: competing risk, cervical cancer, failure patterns Mini-Oral 4872 Sexual dysfunction in cervix cancer survivors after surgery and/or radiochemotherapy: a Bayesian network analysis based on the SENECA study cohort Adriel Ngo 1,2 , Kari Tanderup 3,4 , Therese Juul 4,5 , Gunn Ammitzbøll 6,7 , Jakob Tanderup 8 , Peter Christensen 3,5 , Susanne Dalton 6,9 , Lars U Fokdal 10,11 , Christoffer Johansen 12 , Susanne K Kjær 13,14 , Pernille T Jensen 4,15 , Monica Serban 2,16 1 Medical Biophysics, University of Toronto, Toronto, Canada. 2 Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada. 3 Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark. 4 Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. 5 Department of Surgery, Aarhus University Hospital, Aarhus, Denmark. 6 Cancer Survivorship, Danish Cancer Institute, Copenhagen, Denmark. 7 Departmennt of Clinical Oncology, Zealand University Hospital, Roskilde, Denmark. 8 DTU Compute, Department of Applied Mathematics and Computer Science, Danish Technical University, Kongens Lyngby, Denmark. 9 COMPAS, Dep. for Clin. Oncology and Paliiative Care, Zealand University Hospital, Roskilde, Denmark. 10 Department of Oncology, Vejle Hospital, University of Southern Denmark, Vejle, Denmark. 11 Department of Regional Health Research, University of Southern Denmark, Odense, Denmark. 12 Department of Oncology, Copenhagen University Hospital,
Rigshospitalet, Copenhagen, Denmark. 13 Virus, Lifestyle, and Genes, Danish Cancer Institute, Copenhagen, Denmark. 14 Department of Gynecology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. 15 Dep. of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark. 16 Department of Radiation Oncology, University of Toronto, Toronto, Canada Purpose/Objective: To construct multi-factorial explanatory models of sexual dysfunction using data from participants enrolled in the cross-sectional SENfolger (late effects) Efter Cervix cAncer (SENECA) study. Material/Methods: Patient reported outcomes (PRO) were collected during 2023 from 7792 women with no history of cancer (reference cohort) and 2142 cervical cancer survivors treated between 2005–2022. Patient (age, body mass index), disease (organ involvement), and treatment (radiotherapy, surgery, chemotherapy) information was obtained from the Danish Gynecological Cancer Database and patient-reported data. PROs in the EORTC-C30 and EORTC-CX24 questionnaires were analyzed. Bayesian network models were developed for sexual inactivity and dyspareunia in reference and cancer cohorts, resulting in four explanatory models. The reference cohort was used as a starting point (structural prior) for learning models from the cancer cohort. The sexual inactivity models included all respondents with complete data (6706 reference, 1694 cancer), and the dyspareunia models included respondents who reported being sexually active (‘A little’, ‘Quite a bit’, ‘Very much) in the past four weeks (4521 reference, 996 cancer). Results: Respondents were stratified by treatment modality to obtain cohorts for analysis; (1) Reference group (n=7792), (2) Radiotherapy (radiotherapy ± surgery/chemotherapy,
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