S869
Clinical - Mixed sites & palliation
ESTRO 2026
combined with Adjuvant Radiotherapy in Patients with Painful Bone Metastases: A Retrospective Analysis Lucia Cavero 1 , Palmira Foro 1,2 , C Pusceddu 3 , Isabel Morera Fuster 4 , Ana Montalban Fernandez 2 , Jose Maria Maiques 4 , Albert Solano 4 , Cristina Gutierrez Minguelez 1,2 , Manuel Algara 1,2 , Javier Sanz 1,2 , Ismael Membrive 1,2 , Ana Reig 1 , Yuan Lin 1 , Laura Martinez Avila 1 , Mauricio Hidalgo 1 , Xavier Duran 5 , Salvatore Marsico 4,2 1 Department of Radiation Oncology, Hospital del Mar, Barcelona, Spain. 2 Universitat Pompeu Fabra, Hospital del Mar, Barcelona, Spain. 3 Deparment of Radiology, Mater Olbia Hospital, Olbia, Italy. 4 Deparment of Radiology, Hospital del Mar, Barcelona, Spain. 5 Medical Statistic Unit, Hospital del Mar Research Institute, Barcelona, Spain Purpose/Objective: Palliative radiotherapy (RT) remains the gold standard for the management of painful bone metastases. However, patients presenting with pathological fractures or bone lesions at high risk of fracture may benefit from additional minimally invasive procedures aimed at stabilizing the bone and improving pain control. This retrospective study evaluated pain response in patients treated with image-guided percutaneous ablation and/or cementoplasty followed by adjuvant RT. Material/Methods: A retrospective review was conducted including 13 patients treated between May 2022 and March 2025 at our institution. All patients had painful bone metastases confirmed by imaging and underwent cryoablation, microwave ablation, or cementoplasty / vertebroplasty (with or without SpineJack) followed by RT. Data collected included: primary tumor type, metastatic site, ablative technique, RT dose/fractionation, toxicity, degree of pain after treatment, considering complete response: the patient reports no pain; partial response: the patient reports a decrease in the degree of pain; no response: the pain persists, overall survival (OS), and pain progression- free survival (PFS). Descriptive statistics and Kaplan– Meier survival analysis were performed. Results: The median age was 70 years (57-88); 53.8% were female. The most frequent primary tumors were breast cancer (30.8%), multiple myeloma (23.1%), and lung cancer (15.4%). Metastatic sites were vertebral in 4 patients (30.8%) and pelvic in 9 (69.2%). The most common procedure was cementoplasty (61.6%), followed by microwave ablation (23.1%) and combined ablation plus vertebroplasty with or without SpineJack (15.4%). RT schedules were 20 Gy in 5 fractions (53.8%)
and 8 Gy in a single fraction (15.4%). Pain improvement was observed in 75% of patients, including a complete response in 30.8%. No significant toxicities or procedure-related complications were reported. Median OS was 11.4 months, and median pain PFS was 6.8 months. Conclusion: The integration of image-guided percutaneous ablation and/or cemetoplasty followed by adjuvant radiotherapy represents a safe and effective multimodal strategy for the management of painful bone metastases, particularly in patients with fractures or bone at high risk of fracture. This combined approach enhances pain palliation, provides mechanical stabilization, and contributes to local disease control, complementing the established role of RT in skeletal metastases. A prospective phase II trial is currently ongoing at our institution to further validate these findings and define the optimal treatment sequence. Keywords: Bone metastases, Cementoplasty, Radiotherapy Sleep, quality of life and fatigue in breast and lung cancer patients undergoing radiotherapy: A cross- sectional survey study Atalay Balsak, Namila Nazli, Ozlem Aynaci, Emel Haciislamoglu, Emine Canyilmaz Department of Radiation Oncology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey Purpose/Objective: During cancer treatment, patients experience numerous physical and psychological symptoms, and inadequate management of these symptoms can negatively affect daily functioning and significantly reduce quality of life. ¹ Poor sleep quality, which is commonly observed in cancer patients receiving radiotherapy, contributes to both physical and psychological impairments. Despite this, research on this topic in Türkiye remains limited, and factors influencing sleep quality in patients undergoing radiotherapy have not been sufficiently explored. ² Addressing this gap is essential to improve supportive care strategies. Therefore, this study aims to evaluate sleep quality, quality of life, and fatigue levels in patients diagnosed with breast or lung cancer undergoing radiotherapy. Material/Methods: This prospective study included 90 patients diagnosed with breast or lung cancer and scheduled for definitive Digital Poster 1297
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