S870
Clinical - Mixed sites & palliation
ESTRO 2026
Oncology Units in Amhara Region, Ethiopia. Nat Sci Sleep. 2022;14:1049-1062. Published 2022 Jun 1. doi:10.2147/NSS.S3565972. Zorba P, The determination of relationship between sleeping quality and level of fatigue in subjects under radiotherapy, MSc thesis, 2012 Keywords: Radiotherapy, sleep quality, fatigue
or adjuvant radiotherapy between May and December 2024. Eligible patients had an ECOG performance score of 0–1. The EORTC QLQ-C30, EORTC QLQ-FA12, and Turkish version of the Pittsburgh Sleep Quality Index (PSQI) were administered on the first and last day of radiotherapy, after written and verbal informed consent was obtained. A total PSQI score of ≥ 5 indicates poor sleep quality. Results: Of the 90 patients, 78.9% were female (n=71) and 23.3% had lung cancer (n=21). The median age was 59 years (range 31–85), and the median treatment duration was 39 days (24–56). In total, 57 patients had PSQI ≥ 5 both before and after treatment. Mean PSQI scores did not differ significantly pre- vs post- radiotherapy (6.33 ± 3.57 vs 6.57 ± 3.50; Z = − 0.703, p = 0.482). However, insomnia scores significantly increased following radiotherapy (Z = − 2.607, p = 0.009), as did interference with daily life (Z = − 2.582, p = 0.010). Fatigue (p = 0.059) and pain (p = 0.053) showed borderline increases. Lung cancer patients demonstrated greater deterioration in daily-life interference compared with breast cancer patients (mean rank 55.81 vs 41.66; U = 487.000, p = 0.019). Treatment duration positively correlated with decline in daily-life functioning (rho=0.265, p = 0.013). Pre- and post-radiotherapy scores are shown on Figure1.
Digital Poster 1302 Comparative Validation of Prognostic Indices and the Combined Impact of Diagnostic and Treatment-Related Variables in Patients With Brain Metastases Mehmet Halici, Kimia Cepni, Zeynepnur Sen, Guler Sena Carman, Huriye Senay Kiziltan Radiation Oncology, Ba ş ak ş ehir Çam and Sakura City Hospital, Istanbul, Turkey Purpose/Objective: This study aimed to validate, in a real-world cohort of patients with brain metastases (BM) treated with cranial radiotherapy, the external applicability of widely used prognostic indices and to evaluate the independent and integrative prognostic contribution of both clinical variables at BM diagnosis and treatment-related factors to overall survival (OS) (1). Material/Methods: A total of 116 patients who underwent cranial radiotherapy for BM between 2020 and 2024 at a single institution were retrospectively analyzed. OS was estimated using the Kaplan–Meier method. To identify independent prognostic effects, clinical variables at BM diagnosis and treatment-related factors were first analyzed separately using univariate and multivariate Cox regression models. Variables that remained significant were then entered into a combined multivariate model to assess their integrative prognostic impact. The prognostic performance of four commonly used indices— Recursive Partitioning Analysis (RPA), Graded Prognostic Assessment (GPA), Diagnosis-Specific GPA (ds-GPA), and Basic Score for Brain Metastases (BSBM) (2) —was compared using receiver operating characteristic (ROC) curve and area under the curve (AUC) analyses.
Conclusion: Radiotherapy did not significantly alter overall PSQI scores; however, insomnia symptoms and daily functioning worsened after treatment. Lung cancer patients experienced a greater decline in daily functioning than breast cancer patients, and longer treatment duration was associated with greater impairment. These findings highlight the importance of early symptom screening, individualized supportive interventions, and multidisciplinary approach— incorporating radiation oncology, pulmonology, and psychiatry—to preserve sleep quality and daily functioning during radiotherapy. References: 1. Endeshaw D, Biresaw H, Asefa T, Yesuf NN, Yohannes S. Sleep Quality and Associated Factors Among Adult Cancer Patients Under Treatment at
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