MDM2/XPO1 Inhibition Accumulates Nuclear p53: Enhanced p53 Target Transcription
OCI-AML3
@ 12 hours
160 nM of milademetan, selinexor
Persistent Cells after MDM2/XPO1 Inhibition: High p21 and Upregulated Stress Responses
Multiparameter Flow Panel for Stress Responses
Muftuoglu et al. ASH 2020
DMSO
Mil
Sel
Mil + Sel
OCI-AML3 160 nM of Mil and/or Sel for 48 hours
Triple Inhibition of MDM2, XPO1 and BCL-2 is Highly Effective in Ven/DAC Resistant AML
PDX AML, Ven/DAC R FLT3-ITD, GATA2, NRAS
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