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HERRERA ET AL .
TABLE 4 PICOS questions addressed by each systematic review, listed according to working group: (a) peri-implant health and prevention; (b) management of peri-implant mucositis; (c) management of peri-implantitis — non-surgical; and (d) management of peri-implantitis — surgical.
Reference
Systematic review title
PICOS question (as written in the original article)
(a)
Carra et al. (2023)
Primary prevention of peri-implant diseases: A systematic review and meta-analysis.
What is the efficacy of preventive interventions, involving risk factor control, in patients (i) awaiting dental implant rehabilitation (primordial prevention), or (ii) already having dental implant(s) with healthy peri- implant tissues (primary prevention)? #1. In patients treated for peri-implantitis (P) what is the efficacy of supportive care (I) in comparison with no supportive care (C), in terms of peri-implant tissue stability (O), as reported in prospective and retrospective studies of at least 3 years duration (S). #2. In patients treated for peri-implantitis (P) what is the efficacy of supportive care with adjunctive local antiseptic agents (I) in comparison with supportive care without local antiseptic agents (C), in terms of peri- implant tissue stability (O), as reported in prospective and retrospective studies of at least 3 years duration (S)? #3. In patients treated for peri-implantitis (P) what is the efficacy of supportive care with a frequency of more than once a year (I) in comparison with supportive care with a frequency of once a year or less (C) in terms of peri-implant tissue stability (O), as reported in prospective and retrospective studies of at least 3 years duration (S)? #1. In human subjects suffering peri-implant mucositis (P), has professionally administered non-surgical mechanical/physical therapy (I) any effect over no treatment (C), in terms of clinical/radiographic parameters and invasiveness (O), as shown in randomized clinical trials (RCTs) (S)? #2. In human subjects suffering peri-implant mucositis (P), is any single mode of professionally administered non-surgical mechanical/physical therapy (I) superior to other single modes of professionally administered non-surgical mechanical/physical therapy (C), in terms of clinical/ radiographic parameters and invasiveness (O), as shown in (RCTs) (S)? #3. In human subjects suffering peri-implant mucositis (P), are combinations of treatment modes of professionally administered non- surgical mechanical/physical therapy (I) superior to single modes of professionally administered non-surgical mechanical/physical therapy (C), in terms of clinical/radiographic parameters and invasiveness (O), as shown in (RCTs) (S)? #4. In human subjects suffering peri-implant mucositis (P), does repetition of professionally administered non-surgical mechanical/physical therapy (I) provide added benefits over single administration (C), in terms of clinical/radiographic parameters and invasiveness (O), as shown in (RCTs) (S)? In patients with peri-implant mucositis (P), what is the efficacy of (I) professionally administered topical antibiotics (with unsustained drug release), topical antiseptics (hydrogen peroxide, chlorhexidine, delmopinol hydrochloride, sodium hypochlorite, chitosan, acids) or photodynamic therapy during non-surgical sub-marginal peri-implant instrumentation compared to (C) non-surgical sub-marginal peri-implant instrumentation with or without additional control/placebo treatment in terms of (O) reduction of bleeding on probing (BOP) in (S) RCTs controlled clinical trials, prospective and retrospective case – control- studies, and case series with a follow-up of ≥ 3month? In systemically healthy humans with PiM, what is the efficacy of patient- performed or administered (by prescription) measures used adjunctively to sub-marginal instrumentation, as compared to sub-marginal instrumentation alone or combined with a negative control, in terms of reducing BOP, in randomized controlled clinical trials (RCTs) with at least 3-month follow-up?
Stiesch et al. (2023)
Supportive care for the prevention of disease recurrence/progression following peri- implantitis treatment: A systematic review.
(b)
Non-surgical therapy of peri-implant mucositis — mechanical/physical approaches: A systematic review.
Verket et al. (2023)
Dommisch
Efficacy of chemical approaches during non- surgical sub-marginal instrumentation in the management of peri-implant mucositis: A systematic review.
et al. (2023)
Gennai et al. (2023)
Efficacy of adjunctive measures in peri-implant mucositis. A systematic review and meta- analysis.
(Continues)
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